Ralph Hasenhüttl was sacked on 7 November 2022 due to a poor start to the season, which saw Southampton dragged into the relegation zone.

[7][8] Rubén Sellés took charge until the end of the season, and despite victories over Chelsea and fellow strugglers Leicester City, he was unable to keep Southampton in the Premier League.

[9] On 13 May 2023, Southampton's eleven-year stay in the top flight came to an end after a 2–0 home loss to Fulham resulted in their relegation to the EFL Championship.

[81] Win Draw Loss Fixtures Southampton entered in the second round of the competition and were drawn away to Cambridge United.

[83] A fourth round tie against EFL League One side Lincoln City was drawn next for the Saints.