The 2022–23 Southern Illinois Salukis men's basketball team represented Southern Illinois University Carbondale during the 2022–23 NCAA Division I men's basketball season.

The Salukis were led by fourth-year head coach Bryan Mullins and played their home games at the Banterra Center in Carbondale, Illinois as members of the Missouri Valley Conference.

They finished the season 22–9, 14–6 in MVC Play to tie for 3rd place.

In the MVC tournament, they defeated Missouri State in the quarterfinals before falling to eventual tournament champions Drake in the semifinals.

[1] They lost in the quarterfinals of the MVC tournament to Drake.