The club participated in Serie A and the Coppa Italia.

On 1 July 2022, Spezia announced Luca Gotti as their new head coach on a two-year contract, replacing Thiago Motta.

[1] Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Win Draw Loss Fixtures Source: Soccerway Source: Serie A The league fixtures were announced on 24 June 2022.