The 2022–23 Sydney Sixers Women's season was the eighth in the team's history.

Coached by Charlotte Edwards and captained by Ellyse Perry, the Sixers finished the regular season of WBBL|08 in first position and set a new league record with eleven wins.

They consequently qualified for their fifth Final appearance, returning to the knockout phase of the tournament for the first time since WBBL|04.

In the championship decider, held at North Sydney Oval, the Sixers were defeated in an upset by the Adelaide Strikers.

Personnel changes made ahead of the season included:[2] The table below lists the Sixers players and their key stats (including runs scored, batting strike rate, wickets taken, economy rate, catches and stumpings) for the season.