[1][2][3][4] Tishreen are the defending champions, having won the previous season championship.
A total of 12 teams participate, 10 of which competed in the league campaign during the previous 2021–2022 season.
The league started a week later because on 1 September 2022, mourning was declared for the late president of Tishreen SC, Tarek Zainy, who died in a car accident.
Due to the 2022 FIFA World Cup, the last round before stoppage was held on 21–22 October.
Al-Majd SC and Al-Jazeera SC (promoted to the top flight for the fourth time) earned an automatic promotion thanks to the victory of the 1st Division, replacing Al-Shorta (relegated after sixteen years in the top flight) and Al-Horgelah SC, who finished last in the 2021–22 Syrian Premier League.