Led by former Lady Vol Kellie Harper,[1] entering her fourth year as head coach, the team played its games at Thompson–Boling Arena as members of the Southeastern Conference.

They advanced to the finals of the SEC tournament, where they lost to South Carolina.

[2] Finishing strong in the conference, the Lady Vols earned an at-large bid to the NCAA tournament, advancing to the Sweet Sixteen before losing to Virginia Tech.

[3] The 2021–22 team finished the season 25–9, 11–5 in third place in SEC play.

The Lady Vols also received an at-large bid to the NCAA tournament, where they lost in the Sweet Sixteen to Louisville.