The Lions, led by fifth-year head coach Jaret von Rosenberg, played their home games at Texas A&M–Commerce Field House in Commerce, Texas as members of the Southland Conference.

The Texas A&M–Commerce Lions finished the 2021–22 NCAA Division II men's basketball season 17–9, 9–5 in Lone Star Conference play, to finish in fourth place in conference.

The Lions were defeated by Texas A&M–Kingsville in the first round of the 2022 Lone Star Conference men's basketball tournament.

[1] They were invited to the 2022 NCAA Division II men's basketball tournament.

[2] Their season ended in the tournament's South Central Regional first round with a defeat to first-seeded Lubbock Christian University.