Al Ain were the defending champions after winning their fourteenth title last season.
There was a mid-season break due to the 2022 FIFA World Cup in Qatar.
Shabab Al Ahli won the Pro League for the eighth time.
Emirates would get relegated back to the First Division after a 0–1 home defeat to Al Urooba on the 17th of May.
Note: Flags indicate national team as has been defined under FIFA eligibility rules.