As the title holders, Eintracht Frankfurt qualified for the 2022–23 UEFA Champions League.

[6] Apart from the allocation based on the country coefficients, associations may have had additional teams participating in the Europa League, as noted below: The following is the access list for this season.

When a place was vacated, it was redistributed within the national association by the following rules: The labels in the parentheses show how each team qualified for the place of its starting round: The third qualifying round was divided into Champions Path (CH) and Main Path (MP).

Scheduled kick-off times starting from the group stage were 18:45 and 21:00 CEST/CET, though exceptionally could take place at 16:30 due to geographical reasons.

The draws for the qualifying round were held at the UEFA headquarters in Nyon, Switzerland.

The losers were transferred to the Europa Conference League play-off round of their respective path.

Union Saint-Gilloise made their debut appearance in a UEFA competition group stage.

In the knockout phase, teams played against each other over two legs on a home-and-away basis, except for the one-match final.

The UEFA technical study group selected the following players as the team of the tournament.