The team that scored more goals on aggregate over the two legs remained in League C while the loser was relegated to League D. If the aggregate score was level, extra time was played without applying the away goals rule.

[6] The seeding pots for the league phase were confirmed on 22 September 2021,[7] and were based on the access list ranking.

[2] The draw for the league phase took place at the UEFA headquarters in Nyon, Switzerland on 16 December 2021, 18:00 CET.

Due to restrictions of excessive travel, each group could contain a maximum of one of the following pairs: Northern Ireland and the winner of the Moldova v Kazakhstan play-out tie, Gibraltar and Azerbaijan.

The fixture list was confirmed by UEFA on 17 December 2021, the day following the draw.