The 2022–23 UEFA Youth League Domestic Champions Path began on 12 September and ended on 2 November 2022.
A total of 32 teams competed in the Domestic Champions Path to decide eight of the 24 places in the knockout phase (play-offs and the round of 16 onwards) of the 2022–23 UEFA Youth League.
For the Domestic Champions Path, the 32 teams were drawn into two rounds of two-legged home-and-away ties.
[3] There were no seedings, but the 32 teams were split into groups defined by sporting and geographical criteria prior to the draw.
The team that scores more goals on aggregate over the two legs advances to the next round.
If the aggregate score is level, as the away goals rule has been scrapped early this season, the match will be decided by a penalty shoot-out with no extra time played.
[1] The eight second round winners advance to the play-offs, where they are joined by the eight group runners-up from the UEFA Champions League Path.