The Runnin' Rebels were led by second-year head coach Kevin Kruger and played their home games for the 40th season at the Thomas & Mack Center in Paradise, Nevada.

In the MWC tournament, they defeated Air Force in the first round before losing to Boise State in the quarterfinals.

They were defeated by Wyoming in the first round of the Mountain West tournament to end the season.

Following the departure of coach T.J. Otzelberger to Iowa State, the roster saw a significant amount of turnover from the 2020-21 season.

Only 3 players - Bryce Hamilton, Reece Brown and Trey Hurlburt - returned from the prior season.