The 2022–23 USC Trojans men's basketball team represented the University of Southern California during the 2022–23 NCAA Division I men's basketball season.

The Trojans were led by 10th-year head coach Andy Enfield and played their home games at the Galen Center for the 16th season in Los Angeles, California as members of the Pac-12 Conference.

They received an at-large bid to the NCAA Tournament where they lost in the First Round to Michigan State.

3 seed in the Pac-12 tournament, they defeated Washington in the quarterfinals before losing in the semifinals to UCLA.

7 seed in the Midwest Region, where they lost in the first round to Miami (FL).