Led by head coach Kyle Neptune in his first year as a head coach, the Wildcats played their home games at the Finneran Pavilion on the school's campus in the Philadelphia suburb of Villanova, Pennsylvania and Wells Fargo Center as members of the Big East Conference.

They finished with a record of 16–15, 10–10 to tie for sixth place in regular conference play.

In the 2023 Big East Tournament, they defeated Georgetown in the opening round before losing to Creighton in the quarterfinals.

They defeated St. John's, UConn, and Creighton to win the Big East tournament championship.

On April 20, 2022, head coach Jay Wright announced he was retiring effective immediately.