The 2022–23 West of Scotland Football League (known as the PDM Buildbase West of Scotland League for sponsorship reasons) was the third season of the West of Scotland Football League, with its top division as part of the sixth tier of the Scottish football pyramid system.
Coupled with a 1–1 draw for Darvel at Hurlford United, a 5–0 win for Beith Juniors over Kilwinning Rangers on 29 April 2023 secured the league title.
A 1–1 draw at Benburb on the final day of the season allowed Gartcairn to win the league title by one point ahead of St Cadoc's.
Vale of Clyde became champions on the penultimate weekend of the season, sealing the title with a 5–1 win at East Kilbride Thistle.
SFA Club with an SFA licence;[51] eligible to participate in the Lowland League promotion play-off should they win the Premier Division and take part in the Scottish Cup.