Chelsea successfully defended their title by defeating Reading, whose relegation from the division after an eight-year stint was confirmed by the result, 3–0 on the final matchday.
[6] Mary Earps won the golden glove and broke the record for clean sheets in a WSL season with 14.
Liverpool were confirmed as the 2021–22 FA Women's Championship champions on 3 April 2022, ensuring that they would return to the WSL for the first time since the 2019–20 season after a two year absence.
However, the opening weekend was postponed along with all other football fixture in the country following the death of Elizabeth II, meaning the predicted "record breaking start" to the season off the back of Euro 2022 was on hold.
[20] Everton and West Ham United were the two teams to not play any WSL matches at the club's primary ground during the season.