The season was unusual in that the fixture dates of domestic and European competitions were consistently postponed to accommodate the coverage of the 2022 FIFA World Cup played in November and December 2022 in Qatar.

Wrexham kicked off the season by beating Eastleigh 2–1 in the National League.

Wrexham has traded the top spot back and forth with Notts County throughout the season.

On 7 April, leading up to their second match against one another, Wrexham was second in the league, tied with Notts County at 100 points, behind on goal difference but with a game in hand.

In the FA Cup, they were knocked out in a fourth round replay against EFL Championship side Sheffield United.