Cameron Norrie defeated Alex Molčan in the final, 6–3, 6–7(3–7), 6–1 to win the singles tennis title at the 2022 ATP Lyon Open.

[1] Norrie became the first Briton to win a clay court title on the ATP Tour since 2016.

Stefanos Tsitsipas was the defending champion,[2] but chose not to participate.

The top four seeds receive a bye into the second round.