The 2022 Andalucía Challenger (branded as the 2022 AnyTech365 Andalucía Open for sponsorship reasons) was a professional clay court tennis tournament that took place from 28 March to 3 April 2022 at the Club de Tenis Puente Romano in Marbella, Spain.

It was the fifth edition of the men's event and part of the 2022 ATP Challenger Tour.

[1] It was also the first edition of the women's event and a part of the 2022 WTA 125 calendar.

[2] The following players received wildcards into the singles main draw: The following players received entry into the singles main draw as alternates: The following players received entry from the qualifying draw: The following player received entry as a lucky loser: The following players received wildcards into the singles main draw: The following players entered the main draw using a protected ranking: The following pairs received wildcards into the doubles main draw: