Concurrently, Susana Díaz was replaced as regional PSOE leader by Seville mayor Juan Espadas in June 2021.

The PSOE, which for the first time in history contested a regional election in Andalusia from opposition, got its worst result ever in the autonomous community, while Vox failed to fulfil expectations and saw only modest gains.

[1] Voting for the Parliament was on the basis of universal suffrage, which comprised all nationals over 18 years of age, registered in Andalusia and in full enjoyment of their political rights.

[2] The 109 members of the Parliament of Andalusia were elected using the D'Hondt method and a closed list proportional representation, with an electoral threshold of three percent of valid votes—which included blank ballots—being applied in each constituency.

[1][3][6] The president had the prerogative to dissolve the Parliament of Andalusia and call a snap election, provided that no motion of no confidence was in process and that dissolution did not occur before one year had elapsed since the previous one.

[1][7] In the aftermath of the May 2021 border crisis between Morocco and Spain, Vox announced it would end its confidence and supply arrangement with the PP–Cs coalition government after it became known that the authorities had agreed to take custody of 13 unaccompanied minors from Ceuta.

[10] In November 2021, and amid concerns that parliamentary negotiations would fail to deliver the 2022 budget due to opposition from both the PSOE–A and Vox, it was suggested that a snap election would be called for either 27 February or 6 March, coinciding with the festivities of Andalusia Day.

[23][24] The Parliament of Andalusia was officially dissolved on 26 April 2022 after the publication of the dissolution decree in the BOJA, setting the election date for 19 June and scheduling for the chamber to convene on 14 July.

[39] On 2 February 2022, it was revealed that Podemos, United Left/The Greens–Assembly for Andalusia (IULV–CA), Adelante Andalucía and the Andaluces Levantaos's parties had started talks to probe a prospective electoral alliance of all various parties to the left-wing of the PSOE, in which each would retain a degree of autonomy in parliament, in order to prevent a severe vote dispersion that would deprive them of many seats.

[59][60] In the end, an electoral alliance was agreed between Podemos, IULV–CA, Greens Equo, Green Alliance (AV), Más País and Andalusian People's Initiative (IdPA), but because Podemos and AV failed to fill the required documentation ahead of the legal deadline, both parties found themselves unable to be awarded full party rights within the coalition.

Olona reported the town's PSOE mayor, María Eugenia Rufino González, to the Guardia Civil for alleged abuse of office and deprivation of the right to vote.

The table below lists opinion polling on the perceived likelihood of victory for each party in the event of a regional election taking place.

The election resulted in a landslide victory for the People's Party (PP), with incumbent president Juanma Moreno being re-elected.

Support for the liberal Citizens (Cs) collapsed as a result of vote transfers to the PP, whereas the left-wing vote of the 2018 Adelante Andalucía alliance divided between the United Left (IU) and Podemos-led For Andalusia coalition and the new Adelante Andalucía alliance of former Podemos regional leader Teresa Rodríguez.