Rafael Nadal defeated Daniil Medvedev in the final, 2–6, 6–7(5–7), 6–4, 6–4, 7–5 to win the men's singles tennis title at the 2022 Australian Open.

[2][3] Nadal became the fourth man, after Roy Emerson, Rod Laver, and Djokovic, to achieve the double career Grand Slam, and the second in the Open Era.

1 singles ranking despite being unable to defend his points after Medvedev and Alexander Zverev lost in the final and fourth round, respectively.

Despite being granted a medical exemption to the tournament's COVID-19 vaccine requirement by Tennis Australia,[14] the Australian Border Force confirmed that after being detained at Melbourne Airport for eight hours, Djokovic's visa had been cancelled and he would be denied entry to the country due to not meeting exemption criteria to Australia's vaccination requirements.

[17] On 14 January Minister for Immigration Alex Hawke used his discretionary power under sections 133C(3) and 116(1)(e)(i) of the Migration Act 1958 to cancel Djokovic's visa on health and good order grounds.