Ashleigh Barty defeated Danielle Collins in the final, 6–3, 7–6(7–2) to win the women's singles tennis title at the 2022 Australian Open.

[1] This also marked Barty's last professional appearance, as she announced her retirement from the sport two months later.

[2] Naomi Osaka was the defending champion,[3] but lost to Amanda Anisimova in the third round.

1 singles ranking after Aryna Sabalenka and Barbora Krejčíková lost in the fourth round and quarterfinals, respectively.

The "better of 2020/2021 points" for January, February and March were announced by the WTA in September 2021, even though the 2021 tournament was held three weeks later than in 2022.