[1][2] Deportivo Cali were the defending champions, having won the 2021 Finalización tournament.
Two tournaments (Apertura and Finalización) were played in the season, each one of them being an independent championship.
In the Torneo Apertura Atlético Nacional won their seventeenth league title, beating Deportes Tolima in the finals by a 4–3 aggregate score after winning the first leg in Medellín by a 3–1 score and losing the return leg in Ibagué by two goals to one,[3] and in the Torneo Finalización Deportivo Pereira were the champions, winning their first league title after beating Independiente Medellín on penalties following a 1–1 draw on aggregate in the finals.
[4] The competition format for this season was approved by the General Assembly of DIMAYOR on 17 December 2021:[1] 20 teams took part in the season, the top 18 teams from the relegation table of the previous tournament (2021 Finalización) as well as Cortuluá and Unión Magdalena, who were promoted from the second tournament of the 2021 Primera B season.
Source: Soccerway A separate table was kept to determine the teams that are relegated to the Categoría Primera B for the next season.