Boyacá Chicó were the champions, winning their third Primera B title as well as promotion to the top flight by defeating Atlético Huila by a 3–0 score on aggregate in the season's Grand Final.
[2] The format for the 2022 Primera B season was approved at DIMAYOR's General Assembly session of 17 December 2021.
[5][6] On 20 April 2022 the General Assembly of DIMAYOR approved the reaffiliation of Cúcuta Deportivo, which had been expelled from the entity on 25 November 2020 due to legal issues.
Despite being in the top tier at the moment of its disaffiliation, it was decided that Cúcuta Deportivo would enter the Primera B competition starting from the second half of the 2022 season, with which the tournament expanded to 16 teams.
The best-placed team in the aggregate table, Deportes Quindío, played a double-legged series against the Grand Final losing side Atlético Huila to decide the second and last team promoted to Primera A. Atlético Huila won 2–1 on aggregate and were promoted to Categoría Primera A.