The 2022 Champaign–Urbana Challenger was a professional tennis tournament played on hard courts.

It was the 26th edition of the tournament which was part of the 2022 ATP Challenger Tour.

It took place in Champaign, Illinois, United States between November 14 and November 20, 2022.

The following players received wildcards into the singles main draw: The following players received entry from the qualifying draw: The following player received entry as a lucky loser: