The National League will adopt the designated hitter full-time, a draft lottery will be implemented, the postseason will expand from ten teams to twelve, and advertising patches will appear on player uniforms and helmets for the first time.

[11] In Cleveland's home opener, Ramírez doubled in the ninth inning of a 4–1 defeat to the San Francisco Giants for his 1,000th career hit.

He made his major league debut that same day, starting in right field versus the Detroit Tigers at Comerica Park.

[14] On May 28 versus Detroit, Ramírez homered, tripled and drove in five runs, amounting to an MLB-leading 48 RBI through the Guardians' first 42 games, tied for third-most in club history.

Of all in franchise history, only Manny Ramirez (56 in 1999), Al Rosen (49 in 1954) and Earl Averill (also 48) had equaled or surpassed José Ramírez.

[18] The Guardians set a franchise record with four Gold Glove award winners: Shane Bieber, Andrés Giménez, Steven Kwan, and Myles Straw.