Opening Day was held on April 8 and they hosted their divisional rival, the Chicago White Sox and the season ended on the road against the Seattle Mariners on October 5.

[1] The team wore KB patches in honor of former Tigers player and coach Kimera Bartee who died on December 20, 2021, at the age of 49.

[2] On August 10, after accumulating a 43–68 record, the Tigers fired General Manager Al Avila after 21 seasons with the team.

[3] On September 19, the Tigers hired former San Francisco Giants General Manager Scott Harris as their new President of Baseball Operations.

[7] As a result, the team owners voted unanimously to lockout the players stopping all free agency and trades.