Petra Kvitová defeated the defending champion Jeļena Ostapenko in the final, 6–3, 6–2 to win the women's singles tennis title at the 2022 Eastbourne International.

[1] Ostapenko was aiming to be the first woman to defend the Eastbourne title since Justine Henin in 2007.

All seeds received a bye into the second round.

Click on the seed number of a player to go to their draw section.