The men's 400 metres hurdles at the 2022 European Athletics Championships took place at the Olympiastadion on 17, 18 and 19 August.

[1] All times are local times (UTC+2) First 3 in each heat (Q) and the next 2 fastest (q) advanced to the Semifinals.The 10 highest ranked athletes received a bye into the semifinals[5] First 2 in each semifinal (Q) and the next 2 fastest (q) advance to the Final.

[6] [7]