The women's 100 metres at the 2022 European Athletics Championships took place at the Olympiastadion on 15 and 16 August.

[1] The gold and silver medallists were given the same time of 10.99 seconds, the first time this has happened in the women's 100 metres at these championships since the introduction of fully automatic timing.

All times are local times (UTC+2) First 4 in each heat (Q) and the next 3 fastest (q) advance to the Semifinals.

The nine highest ranked entrants received a bye to the Semifinals[6] First 2 in each Semifinal (Q) and the next 2 fastest (q) advance to the final.

[7] Wind: +0.1 m/s[8]