The women's 400 metres hurdles at the 2022 European Athletics Championships took place in three rounds at the Olympiastadion in Munich, Germany, from 17 to 19 August 2022.

Viivi Lehikoinen set a Finnish record of 54.50 seconds in the semi-finals.

The twelve highest ranked athletes received a bye into the semi-finals.

[9] Two days earlier, she had also won the women's 400 metres, this double victory was unprecedented at the European Athletics Championships.

[10] Viktoriya Tkachuk of Ukraine won the silver medal in 54.30 seconds and Anna Ryzhykova of Ukraine won the bronze medal in 54.86 seconds.