The women's 4 × 100 metres relay at the 2022 European Athletics Championships took place at the Olympiastadion on 19 and 21 August.

[1] First 3 in each heat (Q) and 2 best performers (q) advance to the Final.

[6] [7] In the final, two teams, Great Britain and France, failed to finish, after failing to complete the first baton exchange within the zone.

[8]