Three teams were eligible to participate in the South American pre-qualifiers.

Following suspension of Peru, Bolivia and Ecuador played two-legged match with overall winner advanced to the pre-qualifiers.

[1] Following withdrawals of Nicaragua, Guatemala and Honduras, only three teams were left to play the Central American pre-qualifiers.

Instead, they played single round-robin tournament with winner qualified for the pre-qualifiers.

[5] Due to the COVID-19 pandemic, each group played the November 2020 window at a single venue.