The CAF first round of 2022 FIFA World Cup qualification was played from 4 to 10 September 2019.
[3] The draw for the first round was held on 29 July 2019 at 12:00 EST (UTC+2), at the CAF headquarters in Cairo, Egypt.
[4] The seeding was based on the FIFA World Rankings of July 2019 (shown in parentheses below).
Note: Bolded teams qualified for the second round.
Equatorial Guinea won 2–1 on aggregate and advanced to second round.