The second round of CAF matches for 2022 FIFA World Cup qualification was played over six matchdays, from 1 September to 16 November 2021.
The draw for the second round was held on 21 January 2020, 19:00 CAT (UTC+2), at the Nile Ritz-Carlton in Cairo, Egypt.
[1] The seeding was based on the FIFA World Rankings of December 2019 (shown in parentheses below).
[4] Because the competition was interrupted by the COVID-19 pandemic, the schedule of the second round was revised again and on 19 August 2020 CAF announced the new dates, and the entire second round was postponed to 2021.
[5] On 6 May 2021, the second round was once again postponed due to the pandemic, and all matches were rescheduled to be played between September and November 2021.