Scott McLaughlin of Team Penske scored his first pole in qualifying and claimed his first race victory in the series over Álex Palou, after leading the most laps in the race.

In September 2021, it was announced that St. Petersburg, Florida would host the first race of the 2022 season on February 27, 2022.

[1] Colton Herta was the defending race winner, having won the previous Firestone Grand Prix of St. Petersburg in 2021.

Four rookies made their IndyCar race debut, two of them for A. J. Foyt Enterprises: Kyle Kirkwood made his debut with the team after winning the 2021 Indy Lights championship,[3] alongside former Super Formula and WEC driver Tatiana Calderón, who secured her seat after impressing the team after a test with the team in 2021.

[4] 2021 Indy Lights runner-up David Malukas debuted for Dale Coyne Racing, while Canadian driver Devlin DeFrancesco, who had finished sixth in the 2021 Indy Lights championship, debuted for Andretti Steinbrenner Autosport.