Iga Świątek defeated Coco Gauff in the final, 6–1, 6–3 to win the women's singles tennis title at the 2022 French Open.

This marked only the third time in French Open history that the defending champion lost in the first round (after Anastasia Myskina in 2005 and Jeļena Ostapenko in 2018), and the record 15th consecutive unsuccessful French Open women's singles title defense since 2007.

This was the first edition of the French Open since 2004 to feature three Americans in the quarterfinals: Gauff, Jessica Pegula, and Sloane Stephens.

[7] 17-year-old Linda Nosková was the youngest qualifier to debut in the main draw since Michelle Larcher de Brito in 2009.

[8][9][10][11] This marked only the second time in the Open Era when just one of the top ten seeds reached the fourth round of a major, after 2018 Wimbledon.