The Patriots played their home games at Spuhler Field as a member of the Atlantic 10 Conference.

They were led by head coach Bill Brown, in his 41st season at Mason.

They earned a berth into the 2022 Atlantic 10 Conference baseball tournament, where they were eliminated in game 8 by Richmond.

The Atlantic 10 baseball coaches' poll was released on February 15, 2022.

George Mason was picked to finish tenth in the Atlantic 10.