The 2022 Georgia State Panthers softball team represented Georgia State Panthers during the 2022 NCAA Division I softball season.

The Panthers played their home games at Robert E. Heck Softball Complex.

The Panthers were led by first-year head coach Angie Nicholson and were members of the Sun Belt Conference.

The Sun Belt Conference Coaches Poll was released on January 31, 2022.

Georgia State was picked to finish tenth in the conference with 19 votes.