The regular season started on 21 May and ended on 28 August 2022, followed by the play-offs.
[1] The season culminated in the German Bowl XLIII, which was held on 2 October 2022 in Frankfurt, where the north champion Potsdam Royals met the south champion Schwäbisch Hall Unicorns.
The Unicorns won their 5th German title with a 44–27 victory.
During the regular season each club plays all other clubs in its division twice, home and away, and the teams of the other division of its conference once, resulting in each team playing 10 regular season games.
[1] The eighth placed team in the southern conference enters a two-leg play-off with the winner of the respective conference of the German Football League 2, the second tier of the league system in Germany.