The 2022 Giro di Sicilia (known as Il Giro di Sicilia EOLO for sponsorship reasons) was the 26th edition of the Giro di Sicilia road cycling stage race and the third edition since its revival in 2019.

[1] Three of the 19 UCI WorldTeams, four UCI ProTeams, eleven UCI Continental teams and one national team made up the 19 teams that participated in the race.

[2] Trek–Segafredo, EF Education–Nippo Development Team, Zalf Euromobil Fior and Bardiani–CSF–Faizanè, with six riders each, were the only teams to not enter a full squad of seven riders.

129 riders started the race, of which 91 finished.

[3] UCI WorldTeams UCI ProTeams UCI Continental Teams National Team