Lorenzo Musetti defeated Carlos Alcaraz in the final, 6–4, 6–7(6–8), 6–4 to win the men's singles tennis title at the 2022 Hamburg European Open.

It was his first ATP Tour title, and he saved two match points en route, in his first round match against Dušan Lajović.

[1] Pablo Carreño Busta was the defending champion,[2] but lost in the second round to Alex Molčan.