The 2022 Houston Christian Huskies football team represented Houston Christian University as a member of the Southland Conference during the 2022 NCAA Division I FCS football season.

Led by tenth-year head coach Vic Shealy the Huskies compiled an overall record of 2–9.

The Southland Conference released their preseason poll on July 20, 2022.

[1] Houston Christian finalized their 2022 schedule on February 16, 2022.

[2] Statistics at Gayle and Tom Benson Stadium, San Antonio, TX