The 2022 I.ČLTK Prague Open was a tournament played on outdoor clay.

It was the 29th edition for men and 17th for women, which were respectively part of the 2022 ATP Challenger Tour and the 2022 ITF Women's World Tennis Tour.

It took place in Prague, Czech Republic between 2 and 8 May 2022.

[1] The following players received wildcards into the singles main draw: The following player received entry into the singles main draw using a protected ranking: The following player received entry into the singles main draw as a special exempt: The following player received entry into the singles main draw as an alternate: The following players received entry from the qualifying draw: The following players received entry as lucky losers: The following players received wildcards into the singles main draw: The following player received entry using a protected ranking: The following player received entry as a special exempt: The following players received entry from the qualifying draw: The following player received entry as a lucky loser: