[16] The Two-day format that began in 2019 has been expanded, based on the popularity of the three-round system used for most of the IndyCar road and street courses events.

[21] On Saturday, the procedure will be as follows:[19] On Sunday, time trials will conclude as follows:[19] The 2022 Indianapolis 500 was the sixth race of the 2022 NTT IndyCar Series season.

Newgarden followed up with another win at Long Beach and Pato O'Ward won at Alabama in a time-shortened race (two hours) due to rain.

[26] The GMR Grand Prix, including the Road to Indy races, will again serve as the opening weekend of track activity, on May 14.

[25] The Freedom 100 for the Indy Lights was left off the schedule for the third year in a row, with Roger Penske citing safety as an issue.

[27] The 2022 Indy Lights season will only include a race on the road course during GMR Grand Prix weekend.

[28] * Includes days where trackactivity was significantly limited due to rain Source: 2022 Indianapolis 500 Event Schedule All entries utilized the Dallara DW12 chassis with the Universal Aero Kit 18, with Firestone tires.

Hélio Castroneves (Meyer Shank Racing) and Pato O'Ward (Arrow McLaren SP) were scheduled to participate.

Jimmie Johnson (Ganassi) and Romain Grosjean (Andretti) were scheduled to complete the Rookie Orientation Program during a separate session on October 6.

Rinus VeeKay was fastest in the no-tow rankings, running a lap at 221.551 mph (356.552 km/h) with no aid from aerodynamic drafting.

[67] Rain began to fall on the track just before 2:30 p.m. After roughly one hour, the track was dried and two more runs were completed, but more rain began to fall just before 4:00 p.m., with IndyCar calling an end to Saturday qualifications at roughly 4:50 p.m.[67] Rinus VeeKay was the fastest driver of the day, qualifying with a four-lap average of 233.655 mph (376.031 km/h).

Rinus VeeKay, Álex Palou, Marcus Ericsson, Ed Carpenter, and Tony Kanaan also advanced to the Fast Six round.

[70] After the conclusion of the session, those that qualified for the Fast Six shootout were given a five-minute period behind the pace car to cool their engines down for the next run.

[78] The event was scheduled to start at 2:30 p.m., after Carb Day practice had concluded, but was delayed to 3:30 due to early weather holds.

One incident occurred during the challenge when Sage Karam spun and nearly collided with Felix Rosenqvist in the first round when his Dreyer & Reinbold Racing team failed to secure a tire on his car.

Dixon eventually passed VeeKay for second, allowing him and his teammate Palou to exchange positions regularly to drive to conserve fuel.

On lap 39, VeeKay caused the race's first caution period after losing control of his car in turn two and impacting the outside wall.

Two laps later, with the pits still closed, Palou was forced to take emergency service to prevent running out of fuel, with the penalty being starting at the end of the field for the restart.

Scott Dixon assumed the lead of the race, having stopped just before Ilott's crash, while Conor Daly vaulted up the order to second.

At the halfway mark, Scott Dixon held the lead over Daly, Pato O'Ward, Marcus Ericsson, and Tony Kanaan.

[81] The third caution period of the race came out on lap 106, when Romain Grosjean lost control of his car in turn two and impacted the outside wall.

[86] Racing resumed at lap 158, with Dixon immediately passing O'Ward to take over the lead again, with Felix Rosenqvist third, Conor Daly fourth, and Marcus Ericsson fifth.

Dixon received a drive-through penalty for the mistake, removing him from contention to win despite leading nearly half of the race.

[81][88] The fifth caution period of the day came at lap 194, when Jimmie Johnson lost control of his car in turn two after entering too low, causing him to impact the outside wall.

[81] Racing resumed on lap 199, with Rosenqvist diving to the inside of Kanaan on the restart, allowing Ericsson and O'Ward to gap the duo down the backstretch.

The streaming broadcast on Peacock was not subject to blackout, as the platform does not currently have the ability to enforce such restrictions at a local level.

[95] Former driver James Hinchcliffe joined the NBC broadcast team for 2022 as a color commentator, replacing Paul Tracy, who had been in the role for the previous three years for the race.

Tirico, Patrick, and Earnhardt were also announced as part of the "Peacock Pit Box" crew for mid-race coverage.

Dillon Welch joined the crew as a pit reporter, replacing Kelli Stavast, who had been part of NBC's coverage since 2019.

The chief announcer or "Voice of the 500" for the seventh consecutive year was Mark Jaynes with Davey Hamilton as driver analyst.