The Minnesota Vikings overcame a 33–0 halftime deficit to defeat the visiting Indianapolis Colts 39–36 in overtime and complete the largest comeback in NFL history.

As the game entered the second quarter, the Vikings' defense stood firm, forcing the Colts to kick a field goal.

The two teams then exchanged punts before Vikings quarterback Kirk Cousins threw an interception deep in his own territory that Julian Blackmon returned 17 yards for a touchdown.

The Vikings eventually had to punt, and with four minutes left in the half, the Colts drove the ball downfield and kicked a 27-yard field goal to go into the break with a 33–0 lead.

They opened the fourth quarter with a 20-yard completion from Cousins to Justin Jefferson, and an unnecessary roughness penalty on Rodney Thomas II added another 15 yards.

The Vikings made their way downfield, helped by another unnecessary roughness penalty for a hit on Jefferson by Stephon Gilmore, only for Cousins to throw another interception when targeting Reagor on a deep route that the receiver appeared to give up on.

The Colts started on their own 2-yard line, but could not capitalize on the turnover as the Vikings forced them to punt once again, and Reagor made a fair catch at midfield.

The Vikings used all three of their timeouts during the Colts' drive, but on the first play of the following possession, Dalvin Cook took a screen pass 64 yards downfield for a touchdown.

The Vikings attempted a two-point conversion, and Cousins found T. J. Hockenson in the end zone, tying the game with 2:15 left to play.

The Vikings won the toss ahead of the extra period and elected to receive the ball, but their opening drive stalled following a Cousins sack and an offensive holding penalty against guard Ezra Cleveland.

A 14-yard catch by Hockenson put the Vikings on the verge of Greg Joseph's field goal range, but they declined the 57-yard attempt and punted instead.

After a 6-yard run by Cook, Cousins completed passes to Osborn, Thielen and Jefferson to get the Vikings down to the Colts' 27-yard line with 20 seconds left to play, and a delay of game penalty against Odenigbo moved them 5 yards closer to the end zone.

Despite the Colts using a timeout in an attempt to ice the kicker, Joseph's kick was successful, giving the Vikings a 39–36 win and completing the biggest comeback in NFL history.