The 2022 Internationaux de Tennis de Vendée was a professional tennis tournament played on hard courts.

It was the ninth edition of the tournament which was part of the 2022 ATP Challenger Tour.

It took place in Mouilleron-le-Captif, France between 3 and 9 October 2022.

The following players received wildcards into the singles main draw: The following players received entry into the singles main draw as alternates: The following players received entry from the qualifying draw: The following player received entry as a lucky loser: