The 2022 Internazionali di Tennis Città di Perugia was a professional tennis tournament played on clay courts.

It was the seventh edition of the tournament which was part of the 2022 ATP Challenger Tour.

It took place in Perugia, Italy between 6 and 12 June 2022.

The following players received wildcards into the singles main draw: The following player received entry into the singles main draw as a special exempt: The following players received entry into the singles main draw as alternates: The following players received entry from the qualifying draw: The following player received entry as a lucky loser: