The 35th Annual Nickelodeon Kids' Choice Awards ceremony was held on April 9, 2022, at the Barker Hangar in Santa Monica, California with Miranda Cosgrove and Rob Gronkowski serving as hosts.

As a result of the COVID-19 pandemic, it was the first Kids' Choice Awards ceremony since the 2019 show to feature a live audience.

The ceremony, which was the first since the 2004 show to have two hosts, featured one thousand slimings as well as performances from Kid Cudi and Jack Harlow.

[9] Prior to the ceremony, Owen Holt and Txunamy hosted an Orange Carpet livestream on the Nickelodeon YouTube channel.

[10][11][12] The ceremony featured appearances by celebrities including Jayden Bartels, Brie and Nikki Bella, Sabrina Carpenter, Sofia Carson, Milan Carter, Chance the Rapper, Simon Cowell, Isaiah Crews, Terry Crews, Charli and Dixie D'Amelio, Isla Fisher, Jordan Fisher, Kate Godfrey, Gabrielle Nevaeh Green, Kevin Hart, Samuel L. Jackson, Karl Jacobs, Heidi Klum, Jules LeBlanc, Peyton List, Ralph Macchio, Howie Mandel, Christopher Martinez, Ariana Molkara, MrBeast, Jace Norman, Josh Peck, Charlie Puth, Anton Starkman, Unspeakable, Sofía Vergara, and Xavier Woods.