The 2022 La Flèche Wallonne Féminine was a Belgian road cycling one-day race that took place on 20 April 2022.

It was the 25th edition of La Flèche Wallonne Féminine and the 9th event of the 2022 UCI Women's World Tour.

[3] There were 8 categorised climbs: Seven-time winner of La Flèche Wallonne Féminine Anna van der Breggen retired from the sport at the end of 2021 and therefore did not defend her 2021 title.

[4] In the race itself, a large breakaway of 15 riders was caught before the bottom of the final ascent of the Mur de Huy.

However, Marta Cavalli of FDJ Nouvelle-Aquitaine Futuroscope was able to stay with van Vleuten, and passed her with around 50 metres to go before the line, winning the 2022 edition.